Diflomotecan
Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 220997-97-7
- 分子式: C21H16F2N2O4
- 分子量:398.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
topoisomerase I[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3.4 nM
Compound: 12
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Cytotoxicity against human A549 cells by WST assay
Cytotoxicity against human A549 cells by WST assay
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[PMID: 23578545] |
| A549 | IC50 |
3.4 nM
Compound: 8f
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Cytotoxicity against A549 tumor cell line determined by WST-1 assay
Cytotoxicity against A549 tumor cell line determined by WST-1 assay
|
[PMID: 10841808] |
| HT-29 | IC50 |
8.4 nM
Compound: 8f
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Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay
Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay
|
[PMID: 10841808] |
| T-24 | IC50 |
0.4 nM
Compound: 12
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Cytotoxicity against human chemo-resistant T24 cells by WST assay
Cytotoxicity against human chemo-resistant T24 cells by WST assay
|
[PMID: 23578545] |
| T-24 | IC50 |
0.4 nM
Compound: 8f
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Cytotoxicity against T24 tumor cell line determined by WST-1 assay
Cytotoxicity against T24 tumor cell line determined by WST-1 assay
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[PMID: 10841808] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 220997-97-7
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分子量 398.36
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分子式 C21H16F2N2O4
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SMILES
O=C(OC1)C[C@](O)(CC)C2=C1C(N3CC4=CC5=CC(F)=C(F)C=C5N=C4C3=C2)=O
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別名
BN 80915
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Kroep JR, et al. Diflomotecan, a promising homocamptothecin for cancer therapy. Expert Opin Investig Drugs. 2009;18(1):69-75. [Content Brief]
[2]. Gelderblom H, et al. Phase I pharmacological and bioavailability study of oral diflomotecan (BN80915), a novel E-ring-modified camptothecin analogue in adults with solid tumors. Clin Cancer Res. 2003;9(11):4101-4107. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Diflomotecan 関連分類
HY-13611 関連分類
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