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製品番号: HY-184732

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ERα-IN-3

ERα-IN-3 is a ERα inhibitor with an IC₅₀ of 74.48 μM. ERα-IN-3 induces cell cycle arrest at the G0/G1 and G2/M checkpoints and triggers Apoptosis. ERα-IN-3 exhibits anticancer effects against ER-positive breast cancer. ERα-IN-3 can be used for the research of ERα-positive breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₅H₂₁N₃O₄
分子量:427.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

ERα-IN-3 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

ERα

74.48 μM (IC₅₀)

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

体外実験

ERα-IN-3 (Compound 20) at concentrations of 2-32 μM potently inhibits the proliferation of ER-positive breast cancer cell line T-47D, with an IC₅₀ value of 9.666 μM. Its activity in this cell line is superior to that of Tamoxifen (HY-13757A) and Bazedoxifene (HY-A0031)^[1].
ERα-IN-3 inhibits ERα with an IC₅₀ value of 74.48 μM^[1].
ERα-IN-3 (25 μM; 48 h) induces cell cycle arrest in T-47D cells, primarily at the G0/G1 phase (59.7%), with additional arrest at the G2/M phase (26.3%)^[1].
ERα-IN-3 (25 μM; 48 h) induces apoptosis in approximately 40% of T-47D breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

T-47D
Concentration:

25 μM
Incubation Time:

48 h
Result:

Induced cell cycle arrest with 59.7% of cells in the G0/G1 phase, 9.8% in the S phase, and 26.3% in the G2/M phase.

Apoptosis Analysis^[1]

Cell Line:

T-47D
Concentration:

25 μM
Incubation Time:

48 h
Result:

Induced total apoptosis in approximately 40% of T-47D cells.
Showed early and late apoptotic populations lower than those induced by compound 21 and bazedoxifene but higher than those induced by tamoxifen.

化学情報

分子量 427.45
分子式 C₂₅H₂₁N₃O₄
SMILES

O=[N+](C1=CC(C2=NOC(C3=CN(CC4=CC=CC(OC)=C4)C5=C3C=CC=C5)C2)=CC=C1)[O-]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Das A, et al. Design, synthesis, in vitro and in silico evaluation of novel 5-(1-benzyl-1H-indol-3-yl)-3-phenyl-4,5-dihydroisoxazole derivatives against ER-positive breast cancer. Bioorg Chem. 2026 Jun 15;180:110103. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

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分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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数量:
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ERα-IN-3

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ERα-IN-3 関連分類

HY-184732 関連分類