Evariquinone
Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca2+, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 594860-23-8
- 分子式: C16H12O6
- 分子量:300.26
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
Calcium Channel アイソフォーム固有の製品をすべて表示
More
生物活性
|
ERK1 |
ERK2 |
Evariquinone (10-100 μM) shows concentration-dependent DPPH radical scavenging activity with an IC50 of 42.2 μM and a maximum activity of 70 ± 1.78% at 100 μM[1].
Evariquinone (12-100 μM; 24 h) provides concentration-dependent neuroprotection against 5 mM glutamate-induced cytotoxicity in HT22 cells, restoring cell viability to near control levels at 50 and 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced intracellular ROS accumulation in HT22 cells[1].
Evariquinone (50, 100 μM; 8 h) significantly blocks 5 mM glutamate-induced intracellular Ca2+ influx in HT22 cells, reducing fluorescence intensity to near control levels at 100 μM[1].
Evariquinone (50, 100 μM; 8 h) significantly inhibits 5 mM glutamate-induced phosphorylation of JNK, ERK1/2, and p38 in HT22 cells[1].
Evariquinone (50, 100 μM; 10 h) strongly attenuates 5 mM glutamate-mediated apoptotic cell death in HT22 cells, reducing the percentage of apoptotic cells to ~18% and ~14%, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:immortalized murine hippocampal HT22 neuronal cells
-
Concentration:12-100 μM
-
Incubation Time:24 h
-
Result:Significantly increased cell viability in a concentration-dependent manner; 12 μM increased cell viability to ~50%, 25 μM to ~80%, 50 μM to ~100%, and 100 μM to ~100% relative to control cells.
-
Cell Line:HT22 cells
-
Concentration:50, 100 μM
-
Incubation Time:8 h
-
Result:Significantly reduced glutamate-induced phosphorylation of JNK, ERK1/2, and p38; quantitative analysis showed marked decreases in phosphorylated protein levels relative to the glutamate-only treated group.
-
Cell Line:HT22 cells
-
Concentration:50, 100 μM
-
Incubation Time:10 h
-
Result:Significantly reduced the percentage of annexin V-positive apoptotic cells; glutamate treatment increased apoptotic cells to ~60%, while 50 μM reduced this to ~18% and 100 μM to ~14%.
化学情報
-
CAS 番号 594860-23-8
-
分子量 300.26
-
分子式 C16H12O6
-
SMILES
O=C1C2=C(C(C3=CC(O)=C(C(O)=C13)O)=O)C=C(C=C2OC)C
-
Structure Classification
-
Initial Source
endosymbiotic Emericella variecolor CLB38
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Evariquinone 関連分類
HY-118817 関連分類
Powered by Bioz
- Evariquinone
- 594860-23-8
- Reactive Oxygen Species (ROS)
- Calcium Channel
- JNK
- ERK
- p38 MAPK
- Apoptosis
- mitogen-activated protein kinase
- reactive oxygen species
- c-Jun N-terminal kinase
- calcium ion
- parkinson’s disease
- extracellular signal-regulated kinase 1/2
- HT22 cells
- apoptotic cell death
- alzheimer’s disease
- p38 mitogen-activated protein kinase
- Inhibitor
- inhibitor
- inhibit