FLT3-IN-13
FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC50 values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C20H14N4O2
- 分子量:342.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
IC50: 2.26 μM (TOPO II), 2.26 μM (FLT3)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
0.48 μM
Compound: 5
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Antiproliferative activity against human HL-60 cells
Antiproliferative activity against human HL-60 cells
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[PMID: 37482023] |
FLT3-IN-13 (compound 20) has strong antiproliferative activity against HL-60 with an IC50 of 0.48 ± 0.08 μM[1].
FLT3-IN-13 arrests HL-60 cell cycle at G2/M phase (G1%: 24.76±1.00, S%: 21.26±1.72, G2%: 32.78±2.21, total apoptosis%: 21.36±2.73)[1].
FLT3-IN-13 induces apoptosis of HL-60 with early-apoptosis of 6.13±1.20% and late-apoptosis of 13.06±0.40%[1].
FLT3-IN-13 significantly upregulates P53, TNFα and caspase 3/7 proteins in the HL-60 cell line, and increases the Bax/Bcl-2 ratio[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 342.35
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分子式 C20H14N4O2
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SMILES
O=C1C2=C(C(C(N/N=C/C3=CC=NC=C3)=O)=CC=C2)NC4=C1C=CC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FLT3-IN-13 関連分類
HY-143278 関連分類
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