Pak2 - p21 (RAC1) activated kinase 2 Gene

Also Known as PAK-2; mKIAA4182; D16Ertd269e; 5330420P17Rik; A130002K10Rik

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 224105

About Pak2

Chromosome 16: 31,835,108-31,898,160 reverse strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 297 orthologues, 35 paralogues and is associated with 30 phenotypes. Ubiquitous expression in placenta adult (RPKM 14.2), bladder adult (RPKM 12.7) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including brain and corpus striatum. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pak2 Products (1)

mRNA Protein Name
NM_177326.3 NP_796300.1 serine/threonine-protein kinase PAK 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
18716323 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
23509247 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
28408623 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23509247 MGI
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
23509247 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15182717 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15182717 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15182717 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
15182717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak2 Protein Structure

PBD

PBD: pfam00786 (72 - 129)

STKc_PAK2

STKc_PAK2: cd06655 (228 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 2

  • gamma-PAK

  • p21 protein (Cdc42/Rac)-activated kinase 2

  • p21-activated kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
製品番号 製品名 製品効果
純度 Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-19635 G-5555 Inhibitor 99.88% Unkown
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-120940 AZ13705339 Inhibitor 98.57% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.26% Unkown
HY-171034 PQA-18 Inhibitor 99.62% Unkown
HY-131043 NVS-PAK1-C Inhibitor 99.2% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-182357 PAK1-IN-3 Inhibitor / Unkown
HY-116917 G-9791 Inhibitor / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Pak2 NCBI NCBI:5062