CALU - calumenin Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 813

About CALU

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,739,359-128,773,400 (from NCBI)

This gene has 6 transcripts (splice variants), 281 orthologues and 4 paralogues. Ubiquitous expression in heart (RPKM 44.6), placenta (RPKM 44.1) and 25 other tissues.

Summary

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

CALU Products (5)

mRNA	Protein	Name
NM_001130674.3	NP_001124146.1	calumenin isoform b precursor
NM_001199671.2	NP_001186600.1	calumenin isoform c precursor
NM_001199672.2	NP_001186601.1	calumenin isoform d precursor
NM_001199673.2	NP_001186602.1	calumenin isoform e precursor
NM_001219.5	NP_001210.1	calumenin isoform a precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables calcium ion binding	IDA IDA: Inferred from direct assay	10094503	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18688696	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10222138	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10222138	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	10222138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALU Protein Structure

EF-hand_7

EF-hand_8

0
100
200
300
315 a.a.

Protein Preferred Names	Protein Names
calumenin	IEF SSP 9302

CALU Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CALU	O43852	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CALU Proteins

製品番号	製品名	アクセッション番号	純度
HY-P7713	Calumenin Protein, Human (HEK293, His)	O43852 (K20-F315)	≥ 95%, as determined by reducing SDS-PAGE.

CALU 抗体

製品番号	製品名	アプリケーション	反応性
HY-P80579	Calumenin Antibody (YA813)	WB	Human, Mouse
HY-P80579A	Calumenin Antibody (YA813)(PBS only)	WB	Human, Mouse
HY-P85554	Calumenin Antibody (YA5246)	WB	Human, Mouse

Diseases	Alias
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

阻害性抗体 (1)

製品番号	製品名	製品効果	純度	Phase
HY-P991233	BAT1006	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (24)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-168664	CPD-39	Degrader	98.06%	Unkown
HY-168660	CPD-10		98.59%	Unkown
HY-137246	CD73-IN-3	Inhibitor	99.89%	Unkown
HY-144269	SHR902275	Inhibitor	99.80%	Unkown
HY-119992	CEP-6800	Inhibitor	/	Unkown
HY-149304	SARS-CoV-2-IN-40	Inhibitor	/	Unkown
HY-155014	SARS-CoV-2-IN-44	Inhibitor	/	Unkown
HY-155015	SARS-CoV-2-IN-45	Inhibitor	/	Unkown
HY-155016	SARS-CoV-2-IN-46	Inhibitor	99.77%	Unkown
HY-156325	SARS-CoV-2-IN-62	Inhibitor	/	Unkown
HY-156337	SARS-CoV-2-IN-63	Inhibitor	/	Unkown
HY-156441	SARS-CoV-2-IN-65	Inhibitor	/	Unkown
HY-162313	NIP-22c	Inhibitor	/	Unkown
HY-162492	Influenza A virus-IN-14	Inhibitor	/	Unkown
HY-170850	MKLP2-IN-1	Inhibitor	/	Unkown
HY-RS01849	CALU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-162719	RH12	Inhibitor	/	Unkown
HY-163206	SARS-CoV-2-IN-77	Inhibitor	/	Unkown
HY-168917	9-Aminominocycline	Inhibitor	/	Unkown
HY-173459	N-0920	Inhibitor	/	Unkown
HY-176280	SARS-CoV-2-IN-115	Inhibitor	/	Unkown
HY-N1107	Uzarigenin		/	Unkown
HY-RS19578	Calu Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26075	Calu Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	CALU	VGNC	VGNC:26717
Macaca mulatta	CALU	VGNC	VGNC:70520
Rattus norvegicus	CALU	RGD	RGD:620383
Mus musculus	CALU	MGD	MGI:1097158
Canis familiaris	CALU	VGNC	VGNC:54755
Felis catus	CALU	VGNC	VGNC:69363
Others	CALU	NCBI