2. Anti-infection
  3. SARS-CoV
  4. SARS-CoV-2-IN-46

SARS-CoV-2-IN-46 is a novel coronavirus (SARS-CoV-2) replication inhibitor with an EC50 of 0.9 μM in Calu-3 cells. SARS-CoV-2-IN-46 has antiviral activity and can be used in novel coronavirus (COVID-19) research.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-46 Chemical Structure

SARS-CoV-2-IN-46 Chemical Structure

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5 mg USD 100 In-stock
10 mg USD 160 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

SARS-CoV-2-IN-46 Related Antibodies

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Description

SARS-CoV-2-IN-46 is a novel coronavirus (SARS-CoV-2) replication inhibitor with an EC50 of 0.9 μM in Calu-3 cells. SARS-CoV-2-IN-46 has antiviral activity and can be used in novel coronavirus (COVID-19) research[1].

In Vitro

SARS-CoV-2-IN-46 (Compound 8w) (1-10 μm) inhibites SARS-CoV-2 replication above 50% in Calu-3 cells[1]. SARS-CoV-2-IN-46 (Compound 8w) (250 μm; 72 h) shows low toxicity in Calu-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2-IN-46 Related Antibodies
Molecular Weight

318.27

Formula

C17H12F2O4
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C2=CC=C(OC(F)F)C=C2O/C1=C\C3=CC=C(OC)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (157.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1420 mL 15.7099 mL 31.4199 mL
5 mM 0.6284 mL 3.1420 mL 6.2840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1420 mL 15.7099 mL 31.4199 mL 78.5497 mL
5 mM 0.6284 mL 3.1420 mL 6.2840 mL 15.7099 mL
10 mM 0.3142 mL 1.5710 mL 3.1420 mL 7.8550 mL
15 mM 0.2095 mL 1.0473 mL 2.0947 mL 5.2366 mL
20 mM 0.1571 mL 0.7855 mL 1.5710 mL 3.9275 mL
25 mM 0.1257 mL 0.6284 mL 1.2568 mL 3.1420 mL
30 mM 0.1047 mL 0.5237 mL 1.0473 mL 2.6183 mL
40 mM 0.0785 mL 0.3927 mL 0.7855 mL 1.9637 mL
50 mM 0.0628 mL 0.3142 mL 0.6284 mL 1.5710 mL
60 mM 0.0524 mL 0.2618 mL 0.5237 mL 1.3092 mL
80 mM 0.0393 mL 0.1964 mL 0.3927 mL 0.9819 mL
100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.7855 mL
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SARS-CoV-2-IN-46 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2-IN-46SARS-CoVSARS coronavirusSARS-CoV-2COVID-19 Calu-3 cellsInhibitorinhibitorinhibit

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