SARS-CoV-2-IN-46
Based on 1 Customer Validation
SARS-CoV-2-IN-46 is a novel coronavirus (SARS-CoV-2) replication inhibitor with an EC50 of 0.9 μM in Calu-3 cells. SARS-CoV-2-IN-46 has antiviral activity and can be used in novel coronavirus (COVID-19) research.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 3054787-66-2
- Formula: C17H12F2O4
- Molecular Weight:318.27
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | CC50 |
>300 μM
Compound: 8w
|
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by methylene blue assay
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 72 hrs by methylene blue assay
|
[PMID: 37257024] |
SARS-CoV-2-IN-46 (Compound 8w) (1-10 μm) inhibites SARS-CoV-2 replication above 50% in Calu-3 cells[1]. SARS-CoV-2-IN-46 (Compound 8w) (250 μm; 72 h) shows low toxicity in Calu-3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3054787-66-2
-
Appearance Solid
-
Molecular Weight 318.27
-
Formula C17H12F2O4
-
Color Yellow to orange
-
SMILES
O=C1C2=CC=C(OC(F)F)C=C2O/C1=C\C3=CC=C(OC)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (157.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1420 mL | 15.7099 mL | 31.4199 mL | 78.5497 mL |
| 5 mM | 0.6284 mL | 3.1420 mL | 6.2840 mL | 15.7099 mL | |
| 10 mM | 0.3142 mL | 1.5710 mL | 3.1420 mL | 7.8550 mL | |
| 15 mM | 0.2095 mL | 1.0473 mL | 2.0947 mL | 5.2366 mL | |
| 20 mM | 0.1571 mL | 0.7855 mL | 1.5710 mL | 3.9275 mL | |
| 25 mM | 0.1257 mL | 0.6284 mL | 1.2568 mL | 3.1420 mL | |
| 30 mM | 0.1047 mL | 0.5237 mL | 1.0473 mL | 2.6183 mL | |
| 40 mM | 0.0785 mL | 0.3927 mL | 0.7855 mL | 1.9637 mL | |
| 50 mM | 0.0628 mL | 0.3142 mL | 0.6284 mL | 1.5710 mL | |
| 60 mM | 0.0524 mL | 0.2618 mL | 0.5237 mL | 1.3092 mL | |
| 80 mM | 0.0393 mL | 0.1964 mL | 0.3927 mL | 0.9819 mL | |
| 100 mM | 0.0314 mL | 0.1571 mL | 0.3142 mL | 0.7855 mL |
SARS-CoV-2-IN-46 Related Classifications
HY-155016 Related Classifications
Powered by Bioz