HVCN1 - hydrogen voltage gated channel 1 Gene
Also Known as HV1; VSOP
生物種: Homo sapiens
About HVCN1
This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Broad expression in lymph node (RPKM 18.5), testis (RPKM 16.2) and 21 other tissues.
Summary
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in Other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
HVCN1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001040107.2 | NP_001035196.1 | voltage-gated hydrogen channel 1 isoform 1 |
| NM_001256413.2 | NP_001243342.1 | voltage-gated hydrogen channel 1 isoform 2 |
| NM_032369.4 | NP_115745.2 | voltage-gated hydrogen channel 1 isoform 1 |
HVCN1 Protein Structure
Ion_trans: Ion transport protein (141 - 216)
- 0
- 100
- 200
- 273 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
voltage-gated hydrogen channel 1 |
|
HVCN1 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
HVCN1 | Q96D96 | MUCL1 | Homo sapiens | Q96DR8 | 28514442 | |
|
Intra
|
HVCN1 | Q96D96 | KLHDC10 | Homo sapiens | Q6PID8 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | JCHAIN | Homo sapiens | P01591 | 28514442 | |
|
Intra
|
HVCN1 | Q96D96 | STXBP1 | Homo sapiens | P61764 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | NECTIN2 | Homo sapiens | Q92692 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | DOK2 | Homo sapiens | O60496 | 28514442 | |
|
Intra
|
HVCN1 | Q96D96 | LMNA | Homo sapiens | P02545 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | GSDME | Homo sapiens | O60443 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | STXBP2 | Homo sapiens | Q15833 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | ASAH1 | Homo sapiens | Q13510 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | HVCN1 | Homo sapiens | Q96D96 | 18509058 | |
|
Intra
|
HVCN1 | Q96D96 | FAM91A1 | Homo sapiens | Q658Y4 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | PYCR3 | Homo sapiens | Q53H96 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | CD63 | Homo sapiens | P08962 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | CST1 | Homo sapiens | P01037 | 28514442 | |
|
Intra
|
HVCN1 | Q96D96 | KIF5B | Homo sapiens | P33176 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | HVCN1 | Homo sapiens | Q96D96 | 18509058 | |
|
Intra
|
HVCN1 | Q96D96 | KLC4 | Homo sapiens | Q9NSK0 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | FUS | Homo sapiens | P35637 | 30021884 | |
|
Intra
|
HVCN1 | Q96D96 | KIF5C | Homo sapiens | O60282 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | CHEK1 | Homo sapiens | O14757 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | PIGR | Homo sapiens | P01833 | 28514442 | |
|
Intra
|
HVCN1 | Q96D96 | TANK | Homo sapiens | Q92844 | 33961781 | |
|
Intra
|
HVCN1 | Q96D96 | OXLD1 | Homo sapiens | Q5BKU9 | 28514442 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Hydrolethalus Syndrome 2 |
|
|
| Alzheimer Disease 17 |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Rattus norvegicus | HVCN1 | RGD | RGD:1310788 |
| Bos taurus | HVCN1 | VGNC | VGNC:30010 |
| Felis catus | HVCN1 | VGNC | VGNC:62860 |
| Mus musculus | HVCN1 | MGD | MGI:1921346 |
| Canis familiaris | HVCN1 | VGNC | VGNC:41842 |
| Macaca mulatta | HVCN1 | VGNC | VGNC:73449 |
| Others | HVCN1 | NCBI |