KLHDC10 - kelch domain containing 10 Gene

Also Known as slim; PNAS-138

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23008

About KLHDC10

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,070,534-130,135,705 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 12.0) and 25 other tissues.

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

KLHDC10 Products (1)

mRNA Protein Name
NM_014997.4 NP_055812.1 kelch domain-containing protein 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20562859 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
29779948 GOA
Biological Process GO Annotation Evidence References Source
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
33909987 GOA
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29779948 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
29779948 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
23102700 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHDC10 Protein Structure

Kelch_6

Kelch_6: Kelch motif (92 - 145)

Kelch_4

Kelch_4: Galactose oxidase, central domain (206 - 249)

Kelch_1

Kelch_1: Kelch motif (260 - 304)

Kelch_4

Kelch_4: Galactose oxidase, central domain (315 - 361)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

kelch domain-containing protein 10

  • PNAS-119

KLHDC10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KLHDC10 Q6PID8 NUDCD3 Homo sapiens Q8IVD9
Anti Tag CoIP
20562859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Postpoliomyelitis Syndrome

  • Postpolio Syndrome

  • Post-Polio Syndrome

  • Post Polio Syndrome

  • Polio Late Effects

  • Post-Polio Muscular Atrophy

  • Post-Polio Sequelae

  • Post-Poliomyelitic Syndrome

  • Postpolio Sequelae

  • Postpoliomyelitic Syndrome

  • Postpoliomyelitis Sequelae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07347 KLHDC10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KLHDC10 VGNC VGNC:30634
Macaca mulatta KLHDC10 VGNC VGNC:74102
Mus musculus KLHDC10 MGD MGI:1924038
Rattus norvegicus KLHDC10 RGD RGD:1309792
Felis catus KLHDC10 VGNC VGNC:63135
Canis familiaris KLHDC10 VGNC VGNC:42440
Others KLHDC10 NCBI