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HVCN1 - hydrogen voltage gated channel 1 Gene

Also Known as HV1; VSOP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84329

About HVCN1

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,648,686-110,704,952 (from NCBI)

This gene has 9 transcripts (splice variants), 200 orthologues and 6 paralogues. Broad expression in lymph node (RPKM 18.5), testis (RPKM 16.2) and 21 other tissues.

Summary

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in Other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

HVCN1 Products (3)

mRNA	Protein	Name
NM_001040107.2	NP_001035196.1	voltage-gated hydrogen channel 1 isoform 1
NM_001256413.2	NP_001243342.1	voltage-gated hydrogen channel 1 isoform 2
NM_032369.4	NP_115745.2	voltage-gated hydrogen channel 1 isoform 1

HVCN1 Protein Structure

Ion_trans

0
100
200
273 a.a.

Protein Preferred Names	Protein Names
voltage-gated hydrogen channel 1	voltage sensor domain-only protein

HVCN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HVCN1	Q96D96	MUCL1	Homo sapiens	Q96DR8	Anti Tag CoIP	28514442
Intra	HVCN1	Q96D96	KLHDC10	Homo sapiens	Q6PID8	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	JCHAIN	Homo sapiens	P01591	Anti Tag CoIP	28514442
Intra	HVCN1	Q96D96	STXBP1	Homo sapiens	P61764	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	NECTIN2	Homo sapiens	Q92692	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	DOK2	Homo sapiens	O60496	Anti Tag CoIP	28514442
Intra	HVCN1	Q96D96	LMNA	Homo sapiens	P02545	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	GSDME	Homo sapiens	O60443	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	STXBP2	Homo sapiens	Q15833	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	ASAH1	Homo sapiens	Q13510	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	HVCN1	Homo sapiens	Q96D96	Photoaffinity Labelling	18509058
Intra	HVCN1	Q96D96	FAM91A1	Homo sapiens	Q658Y4	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	PYCR3	Homo sapiens	Q53H96	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	CD63	Homo sapiens	P08962	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	CST1	Homo sapiens	P01037	Anti Tag CoIP	28514442
Intra	HVCN1	Q96D96	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	HVCN1	Homo sapiens	Q96D96	Crosslink	18509058
Intra	HVCN1	Q96D96	KLC4	Homo sapiens	Q9NSK0	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	FUS	Homo sapiens	P35637	Crosslink	30021884
Intra	HVCN1	Q96D96	KIF5C	Homo sapiens	O60282	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	CHEK1	Homo sapiens	O14757	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	PIGR	Homo sapiens	P01833	Anti Tag CoIP	28514442
Intra	HVCN1	Q96D96	TANK	Homo sapiens	Q92844	Anti Tag CoIP	33961781
Intra	HVCN1	Q96D96	OXLD1	Homo sapiens	Q5BKU9	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hydrolethalus Syndrome 2	HLS2 Hydrolethalus Syndrome, Type 2
Alzheimer Disease 17	AD17 Alzheimer'S Disease 17 Alzheimer Disease 17, Late-Onset Alzheimer Disease 17, Late Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W158030	2-Guanidinobezimidazole		95.74%	Unkown
HY-RS06494	HVCN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22565	Hvcn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29084	Hvcn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HVCN1	RGD	RGD:1310788
Bos taurus	HVCN1	VGNC	VGNC:30010
Felis catus	HVCN1	VGNC	VGNC:62860
Mus musculus	HVCN1	MGD	MGI:1921346
Canis familiaris	HVCN1	VGNC	VGNC:41842
Macaca mulatta	HVCN1	VGNC	VGNC:73449
Others	HVCN1	NCBI