Gly-Pro-Glu
Based on 1 Customer Validation
Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.77%
- CAS 番号: 32302-76-4
- 分子式: C12H19N3O6
- 分子量:301.30
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 14.7 μM (glutamate binds to NMDA receptor)[1]
Gly-Pro-Glu (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release[1]. Gly-Pro-Glu (1-1000 μM) shows an inhibition of L-[3H]glutamate binding with an IC50 value of 14.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ovariectomized rats with Abeta25-35 injection[2]
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Dosage:300 mg
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Administration:Intraperitoneal injection; 300 mg per day; on day 0, 6 and 12
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Result:Recovered Abeta25-35-induced the reduction of somatostatin (SRIF) content and SRIF receptor density, and reduced the inhibitory effect of SRIF on adenylyl cyclase activity.
化学情報
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CAS 番号 32302-76-4
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性状 Solid
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分子量 301.30
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分子式 C12H19N3O6
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Color White to off-white
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
1 M HCl : ≥ 100 mg/mL (331.90 mM)
DMSO : 66.67 mg/mL (221.27 mM; ultrasonic and adjust pH to 2 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165(2):766-71. [Content Brief]
[2]. Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15(12):1979-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1 M HCl | 1 mM | 3.3190 mL | 16.5948 mL | 33.1895 mL | 82.9738 mL |
| 5 mM | 0.6638 mL | 3.3190 mL | 6.6379 mL | 16.5948 mL | |
| 10 mM | 0.3319 mL | 1.6595 mL | 3.3190 mL | 8.2974 mL | |
| 15 mM | 0.2213 mL | 1.1063 mL | 2.2126 mL | 5.5316 mL | |
| 20 mM | 0.1659 mL | 0.8297 mL | 1.6595 mL | 4.1487 mL | |
| 25 mM | 0.1328 mL | 0.6638 mL | 1.3276 mL | 3.3190 mL | |
| 30 mM | 0.1106 mL | 0.5532 mL | 1.1063 mL | 2.7658 mL | |
| 40 mM | 0.0830 mL | 0.4149 mL | 0.8297 mL | 2.0743 mL | |
| 50 mM | 0.0664 mL | 0.3319 mL | 0.6638 mL | 1.6595 mL | |
| 60 mM | 0.0553 mL | 0.2766 mL | 0.5532 mL | 1.3829 mL | |
| 80 mM | 0.0415 mL | 0.2074 mL | 0.4149 mL | 1.0372 mL | |
| 100 mM | 0.0332 mL | 0.1659 mL | 0.3319 mL | 0.8297 mL |
Gly-Pro-Glu 関連分類
HY-117483 関連分類
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