32302-76-4
32302-76-4
Chemical Structure
Gly-Pro-Glu
- CAS. Nr.: 32302-76-4
- Formula:C12H19N3O6
- Molecular Weight:301.30
IUPAC Name: glycyl-L-prolyl-L-glutamic acid
InChIKey: JJGBXTYGTKWGAT-YUMQZZPRSA-N
SMILES: O=C(CC[C@H](NC([C@H]1N(CCC1)C(CN)=O)=O)C(O)=O)O
Biological Activity: Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].
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Gly-Pro-Glu | 99.77% | Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection . | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.82
HY-P3528GPR -
Similarity Score 0.80
HY-16757Trofinetide -
Similarity Score 0.78
HY-P4294H-Gly-Pro-Gly-OH -
Similarity Score 0.78
HY-P4488H-Pro-Pro-Gln-OH -
Similarity Score 0.76
HY-118481H-Pro-Glu-OH -
Similarity Score 0.76
HY-P4365D-Pro-Pro-Glu -
Similarity Score 0.75
HY-P3425AGPV -
Similarity Score 0.74
HY-P5237Tetrapeptide-4 -
Similarity Score 0.74
HY-P4850Ac-Pro-Leu-Gly-OH -
Explore the MedChemAI to find more analogs
References
- [1]. Sara VR, et al. Identification of Gly-Pro-Glu (GPE), the aminoterminal tripeptide of insulin-like growth factor 1 which is truncated in brain, as a novel neuroactive peptide. Biochem Biophys Res Commun. 1989 Dec 15;165(2):766-71. [Content Brief]
- [2]. Aguado-Llera D, et al. Gly-Pro-Glu protects beta-amyloid-induced somatostatin depletion in the rat cortex. Neuroreport. 2004 Aug 26;15(12):1979-82. [Content Brief]
