2. Peptides
  3. Gly-Pro-Glu

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection .

For research use only. We do not sell to patients.

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Gly-Pro-Glu Chemical Structure

Gly-Pro-Glu Chemical Structure

CAS No. : 32302-76-4

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Based on 1 publication(s) in Google Scholar

Gly-Pro-Glu Related Antibodies

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Description

Gly-Pro-Glu is a neuroactive peptide with a potent action on acetylcholine release. Gly-Pro-Glu is the N-terminal tripeptide of insulin-like growth factor-I. Gly-Pro-Glu inhibits glutamate binds to N-methyl-D-aspartate (NMDA) receptor with an IC50 value of 14.7 μM. Gly-Pro-Glu can be used for the research of neuroprotection [1][2].

IC50 & Target

IC50: 14.7 μM (glutamate binds to NMDA receptor)[1]
In Vitro

Gly-Pro-Glu (0-100 μM) potentiates the potassium evoked release of both acetylcholine and dopamine, increases K+ evoked acetylcholine release even at concentrations of 0.1 nM and significantly enhances evoked dopamine release[1].
Gly-Pro-Glu (1-1000 μM) shows an inhibition of L-[3H]glutamate binding with an IC50 value of 14.7 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gly-Pro-Glu Related Antibodies
In Vivo

Gly-Pro-Glu (300 mg; i.p. once per day; on day 0, 6 and 12) shows an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized rats with Abeta25-35 injection[2]
Dosage: 300 mg
Administration: Intraperitoneal injection; 300 mg per day; on day 0, 6 and 12
Result: Recovered Abeta25-35-induced the reduction of somatostatin (SRIF) content and SRIF receptor density, and reduced the inhibitory effect of SRIF on adenylyl cyclase activity.
Molecular Weight

301.30

Formula

C12H19N3O6
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (221.27 mM; ultrasonic and adjust pH to 2 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3190 mL 16.5948 mL 33.1895 mL
5 mM 0.6638 mL 3.3190 mL 6.6379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3190 mL 16.5948 mL 33.1895 mL 82.9738 mL
5 mM 0.6638 mL 3.3190 mL 6.6379 mL 16.5948 mL
10 mM 0.3319 mL 1.6595 mL 3.3190 mL 8.2974 mL
15 mM 0.2213 mL 1.1063 mL 2.2126 mL 5.5316 mL
20 mM 0.1659 mL 0.8297 mL 1.6595 mL 4.1487 mL
25 mM 0.1328 mL 0.6638 mL 1.3276 mL 3.3190 mL
30 mM 0.1106 mL 0.5532 mL 1.1063 mL 2.7658 mL
40 mM 0.0830 mL 0.4149 mL 0.8297 mL 2.0743 mL
50 mM 0.0664 mL 0.3319 mL 0.6638 mL 1.6595 mL
60 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3829 mL
80 mM 0.0415 mL 0.2074 mL 0.4149 mL 1.0372 mL
100 mM 0.0332 mL 0.1659 mL 0.3319 mL 0.8297 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gly-Pro-Glu32302-76-4Othersneuroactive peptideNMDAinsulintripeptideacetylcholinedopamineInhibitorinhibitorinhibit

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