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製品番号: HY-157838

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HMC-B17

HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC₅₀ = 1.39 nM) that potentiates anti-PD-L1 efficacy. HMC-B17 potently enhances the IL-2 secretion in Jurkat cells (EC₅₀ = 11.56 nM). HMC-B17 can be used for the research of cancer.

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CAS 番号: 2935913-83-8
分子式: C₂₇H₂₉N₃O₂
分子量:427.54

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HMC-B17 構造式

CAS 番号: 2935913-83-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MAP4K アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
BEAS-2B	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human BEAS-2B cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
Jurkat	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human Jurkat cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
L02	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human L02 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
MCF-10A	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human MCF-10A cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]
WRL68	IC₅₀	>8 μM Compound: F03; HMC-B17	Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay Cytotoxicity against human WRL68 cells incubated for 48 hrs by Cell Titer Glo assay	[PMID: 38350360]

化学情報

CAS 番号 2935913-83-8
分子量 427.54
分子式 C₂₇H₂₉N₃O₂
SMILES

COC1=C(C=C(C=C1)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C5CCN(C)CC5)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zeng S, et al. Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody. Eur J Med Chem. 2024 Mar 5;267:116206. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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HMC-B17

MAP4K アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

HMC-B17 関連分類

HY-157838 関連分類