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Ixekizumab

(別名: LY2439821)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis.

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  • 純度: 99.00%
  • CAS 番号: 1143503-69-8
  • 分子量:146.44 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ixekizumab
  • Experimental Validation Results for Ixekizumab
  • Experimental Validation Results for Ixekizumab
  • Ixekizumab Chemical Structure
    Ixekizumab 構造式
CAS 番号: 1143503-69-8
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609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Ixekizumab. The EC50 for this effect is 4.97 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells with Ixekizumab (HY-P9924, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Ixekizumab Chemical Structure
    1/16
  • Ixekizumab
  • Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Ixekizumab. The EC50 for this effect is 4.97 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells with Ixekizumab (HY-P9924, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).