JAK-IN-33
JAK-IN-33 (compound 3 (R)) is a JAK inhibitor.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3032404-49-9
- 分子式: C24H27N5O5
- 分子量:465.50
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
JAK-IN-33 can be effectively applied in blood[1].
JAK-IN-33 (59 μM, 40 h) can significantly reduce the elevation of GSVA (gene set variation analysis) score stimulated by IL4/IL3 in the human skin, making GSVA score more normal[1].
JAK-IN-33 (59 μM, 40 h) has acceptable stability in the human skin, and can be effectively applied in human skin[1].
JAK-IN-33 (0.324 μL, 40 h) significantly inhibits the expression of TARC and two AD (atopic dermatitis) relevant biomarkers MMP12 and Eotaxin 3 in the Franz cells[1].
JAK-IN-33 is rapidly inactivated in the liver and is expected to have a better targeted systemic safety profile after topical application compares to oral JAK inhibitors repurposed for topical ues.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Franz
-
Concentration:0.324 μL
-
Incubation Time:40 h
-
Result:Significantly inhibited the expression of TARC, MMP12 and Eotaxin 3.
化学情報
-
CAS 番号 3032404-49-9
-
分子量 465.50
-
分子式 C24H27N5O5
-
SMILES
COC[C@H](OC(CC1=CC=C(N=C1)NC2=CC(NC3=CC=CC=C3OC)=C(C=N2)C(N)=O)=O)C
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JAK-IN-33 関連分類
HY-157011 関連分類
Powered by Bioz