MLS000532223
Based on 1 publication(s) in Google Scholar
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.45%
- CAS 番号: 16616-39-0
- 分子式: C15H9NO3
- 分子量:251.24
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 MLS000532223
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生物活性
EC50: 16-120 μM (Rho family GTPases)[1]
MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner[1].
MLS000532223 modulates Rho-family GTP-binding kinetics[1].
MLS000532223 is active in cell-based assays and inhibits EGF-stimulated Rac 1 activation[1].
MLS000532223 inhibits actin rearrangements and changes in cell morphology that are downstream of Rho family GTPase activation[1].
MLS000532223 (10 μM) modulates actin remodeling in mast cells[1].
MLS000532223 (10 μM) inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 16616-39-0
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性状 Solid
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分子量 251.24
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分子式 C15H9NO3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CC([N+]([O-])=O)=C1)C#CC2=CC=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Genomics Proteomics
Integrated Proteomics Reveal ALDH1A1 as an Oncogenic Driver and Regulatory Hub in Hepatocellular Carcinoma. [Abstract]2026 May-Jun;23(3):407-429. PMID: 42055623
溶剤 & 溶解度
DMSO : 50 mg/mL (199.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
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- Norwegian - NO (393 KB)
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- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9803 mL | 19.9013 mL | 39.8026 mL | 99.5064 mL |
| 5 mM | 0.7961 mL | 3.9803 mL | 7.9605 mL | 19.9013 mL | |
| 10 mM | 0.3980 mL | 1.9901 mL | 3.9803 mL | 9.9506 mL | |
| 15 mM | 0.2654 mL | 1.3268 mL | 2.6535 mL | 6.6338 mL | |
| 20 mM | 0.1990 mL | 0.9951 mL | 1.9901 mL | 4.9753 mL | |
| 25 mM | 0.1592 mL | 0.7961 mL | 1.5921 mL | 3.9803 mL | |
| 30 mM | 0.1327 mL | 0.6634 mL | 1.3268 mL | 3.3169 mL | |
| 40 mM | 0.0995 mL | 0.4975 mL | 0.9951 mL | 2.4877 mL | |
| 50 mM | 0.0796 mL | 0.3980 mL | 0.7961 mL | 1.9901 mL | |
| 60 mM | 0.0663 mL | 0.3317 mL | 0.6634 mL | 1.6584 mL | |
| 80 mM | 0.0498 mL | 0.2488 mL | 0.4975 mL | 1.2438 mL | |
| 100 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9951 mL |
MLS000532223 関連分類
HY-117149 関連分類
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