Multi-kinase-IN-13
Multi-kinase-IN-13 (Compound 10F) is an inhibitor of AChE, BuChE, and GSK-3β, with an IC50 of 3 nM against hAChE, 303 nM against hBuChE, and 7.58 nM against GSK-3β. Multi-kinase-IN-13 exhibits in vitro iron chelating activity. AChE-IN-110 can be used in the research of Alzheimer's disease.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C24H18N2O4
- 分子量:398.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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GSK-3β 7.58 nM (IC50) |
hAChE 3 nM (IC50) |
hBCHE 303 nM (IC50) |
Multi-kinase-IN-13 (10 min) potently inhibits hAChE in vitro with an IC50 of 3 nM, which is 2.3 times more potent than Donepezil (HY-14566)[1].
Multi-kinase-IN-13 (0.003-10 μM) inhibits hBuChE in vitro, with an IC50 of 303 nM[1].
Multi-kinase-IN-13 potently inhibits GSK-3β in vitro with an IC50 of 7.58 nM[1].
Multi-kinase-IN-13 (0.003-10 mg/mL) exhibits in vitro iron chelating activity with an IC50 value of 0.162 mg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 398.41
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分子式 C24H18N2O4
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SMILES
O=C(NC1=CC=CC=C1)COC2=CC=C(C=C2)/C=N/C3=CC=C4OC(C=CC4=C3)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Multi-kinase-IN-13 関連分類
HY-182001 関連分類
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