SMU-CX1
Based on 1 Customer Validation
SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 10371-86-5
- 分子式: C18H16N2O
- 分子量:276.33
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38387691] |
| BEAS-2B | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
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Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38387691] |
| HEK-293T | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
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Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38387691] |
| KB | ED50 |
8.7 μg/mL
Compound: 9-methoxy ellipticine
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 7130986] |
| MDCK | CC50 |
5.33 μM
Compound: NSC69187; SMU-CX
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Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against MDCK cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 38387691] |
| R1 | IC50 |
90 μM
Compound: 4
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Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
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[PMID: 18412397] |
| Vero C1008 | CC50 |
>10 μM
Compound: NSC69187; SMU-CX
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability by CCK-8 assay
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[PMID: 38387691] |
化学情報
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CAS 番号 10371-86-5
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性状 Solid
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分子量 276.33
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分子式 C18H16N2O
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Color Light yellow to yellow
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SMILES
COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
SMU-CX1 関連分類
HY-N12110 関連分類
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