WRN-IN-25
WRN-IN-25 is an allosteric Werner syndrome helicase (WRN) inhibitor with an IC50 of 15 nM and a Kd of 54 nM. WRN-IN-25 induces DNA damage, reduces cell viability, and exhibits synthetic lethality in WRN-driven high microsatellite instability cancer cells. WRN-IN-25 can be used in research related to microsatellite instability cancers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C33H38F2N4O4
- 分子量:592.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
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Helicase |
WRN-IN-25 (Compound (AC2) (20 μmol/L top concentration, 1:2 serial dilutions; 72 h) shows that HCT116 cells with WRNI852F mutations are resistant to WRN-IN-25, with WRN-IN-25 inhibiting mutant WRN helicase-mediated DNA unwinding with an IC50 of 312 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 592.68
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分子式 C33H38F2N4O4
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SMILES
O=C(O)CC[C@H](C1=CC=CC=C1)OC2=NC(N3CCN(C(C4=CC=C(C(C)C)C=C4)=O)[C@H](C)C3)=CC(N5CC(F)(F)C5)=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
WRN-IN-25 関連分類
HY-182313 関連分類
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