β-Cyfluthrin
Based on 1 Customer Validation
β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca2+ ATPase involved in calcium transport.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 1820573-27-0
- 分子式: C22H18Cl2FNO3
- 分子量:434.29
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
-
Immunology/Inflammation Compound Library
HY-L007
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Neuronal Signaling Compound Library
HY-L013
-
Neuroprotective Compound Library
HY-L070
-
Calcium Channel Blocker Library
HY-L117
-
Antihypertensive Compound Library
HY-L145
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Ion Channel Compound Library
HY-L166
-
Multi-Target Compound Library
HY-L176
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Pesticide Compound Library
HY-L183
-
High-Throughput Bioactive Compound Library
HY-L205
-
Environmental Pollutant Compound Library
HY-L247
Calcium Channel アイソフォーム固有の製品をすべて表示
More
生物活性
Target: Ca2+ ATPase[1]
β-Cyfluthrin (80 μM, 48 h) reduces the cell viability of primary rat hepatocytes, affects levels of intracellular malondialdehyde (MDA) and nitrate/nitrite, and decreases the activity of superoxide dismutase (SOD)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:rat hepatocytes
-
Concentration:10-80 μM
-
Incubation Time:48 h
-
Result:Inhibited the cell viability.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Female Swiss albino mouse[1]
-
Dosage:20-40 mg/kg
-
Administration:po, once daily for 40 days
-
Result:Reduced the number of grids crossed and standing times in the open field test.
Increased the frequency of urination and defecation, increased the immobility time in the central area.
Increased the number of errors made by mice in the Hebb-Williams maze test.
化学情報
-
CAS 番号 1820573-27-0
-
性状 Solid
-
分子量 434.29
-
分子式 C22H18Cl2FNO3
-
Color White to off-white
-
SMILES
O=C([C@@H]1C(C)(C)C1/C=C(Cl)\Cl)O[C@@H](C#N)C2=CC=C(F)C(OC3=CC=CC=C3)=C2
-
別名
beta-Cyfluthrin
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (115.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.76 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
-
データシート (279 KB)
-
SDS (729 KB)
- English - EN (729 KB)
- Français - FR (729 KB)
- Deutsch - DE (729 KB)
- Norwegian - NO (729 KB)
- Español - ES (729 KB)
- Swedish - SV (729 KB)
- Italian - IT (729 KB)
- Korean - KR (729 KB)
- Portuguese - PT (729 KB)
-
取扱説明書 (2659 KB)
参考文献
[1]. Neelu Kanwar Rajawat, et al. Effect of β-cyfluthrin (Synthetic Pyrethroid) on Learning, Muscular Coordination and Oxidative Stress in Swiss Albino Mice. Toxicol Ind Health. 2019 May;35(5):358-367. [Content Brief]
[2]. Mousavi L, et al., β-Cyfluthrin-Mediated Cytotoxicity of Cultured Rat Primary Hepatocytes Ameliorated by Cotreatment with Luteolin. Evid Based Complement Alternat Med. 2022 Aug 27;2022:3647988. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3026 mL | 11.5130 mL | 23.0261 mL | 57.5652 mL |
| 5 mM | 0.4605 mL | 2.3026 mL | 4.6052 mL | 11.5130 mL | |
| 10 mM | 0.2303 mL | 1.1513 mL | 2.3026 mL | 5.7565 mL | |
| 15 mM | 0.1535 mL | 0.7675 mL | 1.5351 mL | 3.8377 mL | |
| 20 mM | 0.1151 mL | 0.5757 mL | 1.1513 mL | 2.8783 mL | |
| 25 mM | 0.0921 mL | 0.4605 mL | 0.9210 mL | 2.3026 mL | |
| 30 mM | 0.0768 mL | 0.3838 mL | 0.7675 mL | 1.9188 mL | |
| 40 mM | 0.0576 mL | 0.2878 mL | 0.5757 mL | 1.4391 mL | |
| 50 mM | 0.0461 mL | 0.2303 mL | 0.4605 mL | 1.1513 mL | |
| 60 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9594 mL | |
| 80 mM | 0.0288 mL | 0.1439 mL | 0.2878 mL | 0.7196 mL | |
| 100 mM | 0.0230 mL | 0.1151 mL | 0.2303 mL | 0.5757 mL |
β-Cyfluthrin 関連分類
HY-B1837A 関連分類
Powered by Bioz