Effect of β-cyfluthrin (synthetic pyrethroid) on learning, muscular coordination and oxidative stress in Swiss albino mice

  • Toxicol Ind Health. 2019 May;35(5):358-367. doi: 10.1177/0748233719840957.
Neelu Kanwar Rajawat  1 ,  Inderpal Soni  2 ,  Farah Syed  2 ,  Rajbala Verma  2 ,  P J John  2 ,  Reena Mathur  2
Affiliations
  • 1. 1 Department of Zoology, The IIS University, Jaipur, India.
  • 2. 2 Environmental Toxicology Lab, Department of Zoology, University of Rajasthan, Jaipur, India.
PMID: 31096887 DOI: 10.1177/0748233719840957
Abstract

The present study was planned to evaluate neurotoxic effects of β-cyfluthrin in female Swiss albino mice. Two doses of β-cyfluthrin, specifically, one-tenth of median lethal dose (LD50) and one-twentieth of LD50, were selected for the study. Open-field behaviour, exploratory behaviour and emotional status were affected, and Animals showed anxiety-like behaviour after β-cyfluthrin administration. Spatial learning was decreased using the Hebb-Wiliams maze. Acetylcholinesterase enzyme activity significantly decreased in the treated Animals. The administration of β-cyfluthrin caused increased lipid peroxidation (malondialdehyde) and decreased superoxide dismutase, catalase and Glutathione Peroxidase activity in brain tissue. In conclusion, β-cyfluthrin caused neurotoxicity as well as oxidative damage in the brain of Swiss albino mice at the tested dose levels.

Keywords
learning; locomotory behaviour; neuromuscular coordination; oxidative stress; β-Cyfluthrin.
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