country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-151287

Copy Link Print Information

KRAS inhibitor-20

KRAS inhibitor-20 is a small molecular inhibitor of KRas^G12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRas^G12C with the IC50 value <10 nM.

For research use only. We do not sell to patients.

CAS No.: 2411786-32-6
Formula: C₃₁H₄₀F₄N₆O₂
Molecular Weight:604.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

KRAS inhibitor-20 Chemical Structure

CAS No.: 2411786-32-6

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

KRAS inhibitor-20 is a small molecular inhibitor of KRas^G12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRas^G12C with the IC50 value <10 nM^[1].

IC₅₀ & Target^[1]

KRAS(G12C)

<10 nM (IC₅₀, ^[1])

All Ras Isoforms :

In Vitro

KRAS inhibitor-20 (compound 12b) results KRas^G12C alkylation human lung cancer adenocarcinoma (HCC 1171) with an EC₅₀ value of 3.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2411786-32-6
Molecular Weight 604.68
Formula C₃₁H₄₀F₄N₆O₂
SMILES

C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

KRAS inhibitor-20

All Ras Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KRAS inhibitor-20 Related Classifications

HY-151287 Related Classifications