SMK-17
SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations.
For research use only. We do not sell to patients.
- CAS No.: 765958-29-0
- Formula: C20H24ClF2IN4O2S
- Molecular Weight:584.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 765958-29-0
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Molecular Weight 584.85
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Formula C20H24ClF2IN4O2S
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SMILES
O=S(NC1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)(N3CCC(CC3)NC(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SMK-17 Related Classifications
HY-12447 Related Classifications
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