765958-29-0
765958-29-0
Chemical Structure
SMK-17
- CAS No.: 765958-29-0
- Formula:C20H24ClF2IN4O2S
- Molecular Weight:584.85
IUPAC Name: N-(2-((2-chloro-4-iodophenyl)amino)-3,4-difluorophenyl)-4-(isopropylamino)piperidine-1-sulfonamide
InChIKey: WEULUYVOTSCFRJ-UHFFFAOYSA-N
SMILES: O=S(NC1=CC=C(C(F)=C1NC2=CC=C(C=C2Cl)I)F)(N3CCC(CC3)NC(C)C)=O
Biological Activity: SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations[1].
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SMK-17 | SMK-17 is a selective, non-ATP-competitive MEK1/MEK2 inhibitor with IC50s of 62 nM and 56 nM, respectively. SMK-17 binds to the allosteric pocket of MEK1/2. SMK-17 induces apoptosis in tumor cell lines harboring β-catenin mutations. | |||||||||||||||||||||
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References
Keywords
