6-Hydroxynicotinic acid
Based on 1 Customer Validation
6-Hydroxynicotinic acid is an intermediate in the oxidation of Nicotinic acid (HY-B0143) by Pseudomonas fluorescens and metabolite. 6-Hydroxynicotinic acid can be isolated from root exudates of Cucumis melo. 6-Hydroxynicotinic acid disrupts the Auxin signaling pathway. 6-Hydroxynicotinic acid inhibits haustoria precursor formation in Phlipanche aegyptiaca.
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- Purity: 99.83%
- CAS No.: 5006-66-6
- 화학식: C6H5NO3
- 분자량:139.11
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보관:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
6-Hydroxynicotinic acid (0.01-1 mM) inhibits prehaustorium formation in Phelipanche aegyptiaca in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5006-66-6
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Appearance Solid
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분자량 139.11
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화학식 C6H5NO3
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(O)N=C1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
용액&용해도
DMSO : 33.33 mg/mL (239.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (14.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.43 mg/mL (10.28 mM); Clear solution
This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.43 mg/mL (10.28 mM); Clear solution
This protocol yields a clear solution of ≥ 1.43 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (14.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 1 mg/mL (7.19 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
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- Korean - KR (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Hu X, et al. 6-Hydroxynicotinic Acid From Cucumis melo Inhibits Prehaustorium Formation in Phelipanche aegyptiaca via Disruption of Auxin Signalling Pathway. Mol Plant Pathol. 2025 Aug;26(8):e70137. [Content Brief]
[2]. HUGHES DE. 6-Hydroxynicotinic acid as an intermediate in the oxidation of nicotinic acid by Pseudomonas fluorescens. Biochem J. 1955 Jun;60(2):303-10. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 7.1886 mL | 35.9428 mL | 71.8856 mL | 179.7139 mL |
| 5 mM | 1.4377 mL | 7.1886 mL | 14.3771 mL | 35.9428 mL | |
| 10 mM | 0.7189 mL | 3.5943 mL | 7.1886 mL | 17.9714 mL | |
| DMSO | 15 mM | 0.4792 mL | 2.3962 mL | 4.7924 mL | 11.9809 mL |
| 20 mM | 0.3594 mL | 1.7971 mL | 3.5943 mL | 8.9857 mL | |
| 25 mM | 0.2875 mL | 1.4377 mL | 2.8754 mL | 7.1886 mL | |
| 30 mM | 0.2396 mL | 1.1981 mL | 2.3962 mL | 5.9905 mL | |
| 40 mM | 0.1797 mL | 0.8986 mL | 1.7971 mL | 4.4928 mL | |
| 50 mM | 0.1438 mL | 0.7189 mL | 1.4377 mL | 3.5943 mL | |
| 60 mM | 0.1198 mL | 0.5990 mL | 1.1981 mL | 2.9952 mL | |
| 80 mM | 0.0899 mL | 0.4493 mL | 0.8986 mL | 2.2464 mL | |
| 100 mM | 0.0719 mL | 0.3594 mL | 0.7189 mL | 1.7971 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
6-Hydroxynicotinic acid Related Classifications
HY-W001996 Related Classifications
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