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Cat. No.: HY-16965A

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TH287 hydrochloride

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC₅₀ of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research.

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CAS No.: 1638211-05-8
화학식: C₁₁H₁₁Cl₃N₄
분자량:305.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

TH287 hydrochloride Chemical Structure

CAS No.: 1638211-05-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
순도&문서
References
Calculators
Help & FAQs
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 0.8 nM (MTH1)^[1]

All DNA/RNA Synthesis Isoforms :

In Vitro

TH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TH287 (5 mg/kg; i.p.) exhibits C_max of 0.82 μM and t_max of 0.5 h in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1638211-05-8
분자량 305.59
화학식 C₁₁H₁₁Cl₃N₄
SMILES

NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Sci Adv

A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding. [Abstract]

2026 Jan 30;12(5):eadx5130. PMID: 41616049
Acta Biomater

Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma. [Abstract]

2020 Jun;109:229-243. PMID: 32294550
J Mol Med (Berl)

Combination of PARP inhibitor and temozolomide to suppress chordoma progression. [Abstract]

2019 Aug;97(8):1183-1193. PMID: 31201471

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21. [Content Brief]

[2]. Saleh A, et, al. Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma. J Pharm Biomed Anal. 2015 Feb;104:1-11. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TH287 hydrochloride

3 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (3)
순도&문서
References

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TH287 hydrochloride

Publications Citing Use of MedChemExpress (MCE) TH287 hydrochloride

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (3)

순도&문서

References

Calculators

Help & FAQs

TH287 hydrochloride Related Classifications

HY-16965A Related Classifications