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Cat. No.: HY-182432

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A3AR antagonist-7

A3AR antagonist-7 is a conjugable human A3 adenosine receptor (A3AR) antagonist with a K_i value of 31.8 nM. A3AR antagonist-7 is applicable to the research of melanoma, breast cancer and colorectal cancer.

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CAS No.: 2672534-18-6
화학식: C₅₆H₇₁N₁₅O₁₂S₂
분자량:1210.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

A3AR antagonist-7 Chemical Structure

CAS No.: 2672534-18-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

Adenosine A₃ receptor

31.8 nM (Ki)

All Adenosine Receptor Isoforms :

In Vitro

A3AR antagonist-7 (Compound 23) binds to hA₃AR expressed in CHO cells with a K_i of 31.8 nM, shows lower affinity for hA_2AAR expressed in HEK293 cells (K_i = 90 nM), and has undetermined binding to hA₁AR expressed in CHO cells, with a hA_2AAR/hA₃AR selectivity ratio of 2.83^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2672534-18-6
분자량 1210.39
화학식 C₅₆H₇₁N₁₅O₁₂S₂
SMILES

O=C(C1=C(C2=C(C=CC(N)=C3S(=O)(O)=O)C3=[O+]C4=C2C=CC(N)=C4S(=O)(O)=O)C=CC(C(NCCCCCCN5N=NC(CCCC(NC6=NC7=NN(C)C=C7C8=NC(C9=CC=CO9)=NN68)=O)=C5)=O)=C1)[O-].CCN(CC)CC.CCN(CC)CC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Federico S, et al. Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes. Eur J Med Chem. 2020 Jan 15;186:111886.
[Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
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A3AR antagonist-7

All Adenosine Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

A3AR antagonist-7 Related Classifications

HY-182432 Related Classifications