AH-7614
Based on 6 publication(s) in Google Scholar
AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). AH-7614 is able to block effects of both the polyunsaturated ω-6 fatty acid linoleic acid and the synthetic FFA4 agonist.
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- Purity: 99.61%
- CAS No.: 6326-06-3
- 화학식: C20H17NO3S
- 분자량:351.42
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) AH-7614
More- Adv Sci (Weinh). 2025 Jan 21:e2407942. [Abstract]
- Cell Death Discov. 2024 Jul 19;10(1):329. [Abstract]
- EMBO Rep. 2024 Dec;25(12):5507-5536. [Abstract]
- Biochem Pharmacol. 2024 Dec;230(Pt 1):116575. [Abstract]
- J Nutr Biochem. 2025 Jan:135:109772. [Abstract]
- Animals (Basel). 2025 Nov 26;15(23):3418. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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WB
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Bio/Physico-chemical Assay
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Cell Imaging/Staining
Biological Activity
pIC50: 7.1 (human FFA4)[1]
AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells[1].
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells[1].
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70)[2].
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
AH7614 (50 μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibits tumor progression by blocking GPR120 signaling in combination with Epirubicin[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6326-06-3
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Appearance Solid
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분자량 351.42
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화학식 C20H17NO3S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
HACD2 Promotes Pancreatic Cancer Progression by Enhancing PKM2 Dissociation From PRKN in a Dehydratase-Independent Manner. [Abstract]2025 Jan 21:e2407942. PMID: 39836601
AH-7614 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 21:e2407942. [Abstract]
Quantification of the proliferation of AsPC-1 and PANC-1 cells treated for 24 h with 50 nM AH-7614 or vehicle via CCK-8 (n = 4) assays.
AH-7614 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jan 21:e2407942. [Abstract]
Quantification of the proliferation of AsPC-1 and PANC-1 cells treated for 24 h with 50 nM AH-7614 or vehicle in colony formation (n = 3) assays.
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Cell Death Discov
2024 Jul 19;10(1):329. PMID: 39030174 -
EMBO Rep
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy. [Abstract]2024 Dec;25(12):5507-5536. PMID: 39482491
AH-7614 purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2024 Dec;25(12):5507-5536. [Abstract]
To verify the efficacy of AH7614 (100 μM, pretreatment for 1 hour), protein level of GPR120 was determined in RAW264.7 cells.
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Biochem Pharmacol
Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR120. [Abstract]2024 Dec;230(Pt 1):116575. PMID: 39396646 -
J Nutr Biochem
A natural small molecule pinocembrin resists high-fat diet-induced obesity through GPR120-ERK1/2 pathway. [Abstract]2025 Jan:135:109772. PMID: 39313008
AH-7614 purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Jan:135:109772. [Abstract]
Representative Oil Red O (ORO) staining and relative ORO optical density (OD) value of DMSO control, AH7614 (10 μM), 30 µM PB, or AH7614+30 µM PB-treated preadipocytes.
AH-7614 purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Jan:135:109772. [Abstract]
Representative BODIPY staining and relative quantification of preadipocytes treated with DMSO control, AH7614 (10 μM), 30 µM PB, or AH7614+30 µM PB.
AH-7614 purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Jan:135:109772. [Abstract]
Representative immunoblotting analysis and qualification of HSL, FASN, CEBPβ, PPARγ in preadipocytes treated with DMSO control, AH7614 (10 μM), 30 µM PB, or AH7614+30 µM PB.
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Animals (Basel)
Divergent Regulation of Mammary Lipogenesis by trans-10, cis-12 and cis-9, trans-11 CLA Isomers Is Determined by Receptor-Specific Signaling. [Abstract]2025 Nov 26;15(23):3418. PMID: 41375476
용액&용해도
DMSO : 100 mg/mL (284.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Sparks SM, et, al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. [Content Brief]
[2]. Watterson KR, et, al. Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4. Mol Pharmacol. 2017 Jun;91(6):630-641. [Content Brief]
[3]. Wang X, et, al. Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis. EBioMedicine. 2019 Feb;40:251-262. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8456 mL | 14.2280 mL | 28.4560 mL | 71.1399 mL |
| 5 mM | 0.5691 mL | 2.8456 mL | 5.6912 mL | 14.2280 mL | |
| 10 mM | 0.2846 mL | 1.4228 mL | 2.8456 mL | 7.1140 mL | |
| 15 mM | 0.1897 mL | 0.9485 mL | 1.8971 mL | 4.7427 mL | |
| 20 mM | 0.1423 mL | 0.7114 mL | 1.4228 mL | 3.5570 mL | |
| 25 mM | 0.1138 mL | 0.5691 mL | 1.1382 mL | 2.8456 mL | |
| 30 mM | 0.0949 mL | 0.4743 mL | 0.9485 mL | 2.3713 mL | |
| 40 mM | 0.0711 mL | 0.3557 mL | 0.7114 mL | 1.7785 mL | |
| 50 mM | 0.0569 mL | 0.2846 mL | 0.5691 mL | 1.4228 mL | |
| 60 mM | 0.0474 mL | 0.2371 mL | 0.4743 mL | 1.1857 mL | |
| 80 mM | 0.0356 mL | 0.1778 mL | 0.3557 mL | 0.8892 mL | |
| 100 mM | 0.0285 mL | 0.1423 mL | 0.2846 mL | 0.7114 mL |
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