DPTN dihydrochloride
Based on 1 Customer Validation
DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.47%
- CAS No.: 325767-87-1
- 화학식: C22H20Cl2N4OS
- 분자량:459.39
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Biological Activity
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hA3 1.65 nM (Ki) |
DPTN is indeed a potent antagonist for human, mouse, and rat A3ARs . DPTN is weaker at mouse and rat compared with human A3AR and has reduced selectivity (about 20-fold vs A2BAR).[1]. The Binding affinity of BNPT (10 μM) is tested in membranes of transfected HEK293 cells, the Ki values are 162 ± 49, 121 ± 42, 230 ± 40, and 1.65 ± 0.57 nM for hA1, hA2A, hA2B, and hA3, respectively[1]. DPTN’s Ki values at respective A1, A2A, A2B, and A3 receptors are 411, 830, 189, and 9.61 nM (mouse); and 333, 1147, 163, and 8.53 nM (rat) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 325767-87-1
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Appearance Solid
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분자량 459.39
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화학식 C22H20Cl2N4OS
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=CN=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 5 mg/mL (10.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1768 mL | 10.8840 mL | 21.7680 mL | 54.4200 mL |
| 5 mM | 0.4354 mL | 2.1768 mL | 4.3536 mL | 10.8840 mL | |
| 10 mM | 0.2177 mL | 1.0884 mL | 2.1768 mL | 5.4420 mL |
DPTN dihydrochloride Related Classifications
HY-153152 Related Classifications
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