Exatecan Intermediate 2 hydrochloride
Based on 1 Customer Validation
Exatecan Intermediate 2 hydrochloride (Compound B) is an intermediate of Exatecan (DX-8951, HY-13631). Exatecan is an anticancer agent belonging to the class of camptothecin analogs. Exatecan interferes with the proliferation and division of tumor cells by interacting with DNA, thereby inhibiting tumor growth. Exatecan is primarily used for research of a variety of cancers including ovarian, lung and breast cancers.
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- Purity: 99.94%
- CAS No.: 2437603-23-9
- 화학식: C13H16ClFN2O2
- 분자량:286.73
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Camptothecins |
Camptothecin derivatives are a class of cytotoxic small molecules that can be used in the preparation of antibody-drug conjugates. Camptothecin derivatives generally exhibit antitumor effects by inhibiting topoisomerase I[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2437603-23-9
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Appearance Solid
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분자량 286.73
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화학식 C13H16ClFN2O2
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Color Off-white to gray
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SMILES
CC(NC(CCC1=C2C(N)=CC(F)=C1C)C2=O)=O.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 12.5 mg/mL (43.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4876 mL | 17.4380 mL | 34.8760 mL | 87.1900 mL |
| 5 mM | 0.6975 mL | 3.4876 mL | 6.9752 mL | 17.4380 mL | |
| 10 mM | 0.3488 mL | 1.7438 mL | 3.4876 mL | 8.7190 mL | |
| 15 mM | 0.2325 mL | 1.1625 mL | 2.3251 mL | 5.8127 mL | |
| 20 mM | 0.1744 mL | 0.8719 mL | 1.7438 mL | 4.3595 mL | |
| 25 mM | 0.1395 mL | 0.6975 mL | 1.3950 mL | 3.4876 mL | |
| 30 mM | 0.1163 mL | 0.5813 mL | 1.1625 mL | 2.9063 mL | |
| 40 mM | 0.0872 mL | 0.4360 mL | 0.8719 mL | 2.1798 mL |
Exatecan Intermediate 2 hydrochloride Related Classifications
HY-W021377A Related Classifications
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