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LSM3 - LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated Gene

Also Known as SMX4; USS2; YLR438C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27258

About LSM3

Cytogenetic location: 3p25.1 Genomic coordinates (GRCh38): 3:14,178,817-14,201,122 (from NCBI)

This gene has 1 transcript (splice variant) and 205 orthologues. Ubiquitous expression in kidney (RPKM 53.9), fat (RPKM 40.8) and 25 other tissues.

Summary

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

LSM3 Products (1)

mRNA	Protein	Name
NM_014463.3	NP_055278.1	U6 snRNA-associated Sm-like protein LSm3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables U6 snRNA 3'-end binding	IDA IDA: Inferred from direct assay	10369684	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14667819	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	10369684	GOA
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Lsm2-8 complex	IDA IDA: Inferred from direct assay	10523320	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	10369684	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26912367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSM3 Protein Structure

LSM

0
102 a.a.

Protein Preferred Names	Protein Names
U6 snRNA-associated Sm-like protein LSm3	LSM3 U6 small nuclear RNA and mRNA degradation associated

LSM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LSM3	P62310	TFIP11	Homo sapiens	Q9UBB9	BFG-2H	27107012
Intra	LSM3	P62310	TFIP11	Homo sapiens	Q9UBB9	Anti Tag CoIP	33961781
Intra	LSM3	P62310	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	LSM3	P62310	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	LSM3	P62310	LSM2	Homo sapiens	Q9Y333	Y2H	15231747
Intra	LSM3	P62310	LSM1	Homo sapiens	O15116	Y2H Array	25416956
Intra	LSM3	P62310	LSM1	Homo sapiens	O15116	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	LSM3	P62310	LSM1	Homo sapiens	O15116	Y2H	15231747
Intra	LSM3	P62310	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	LSM8	Homo sapiens	O95777	Y2H	15231747
Intra	LSM3	P62310	LSM8	Homo sapiens	O95777	Y2H Array	21988832
Intra	LSM3	P62310	LSM8	Homo sapiens	O95777	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM8	Homo sapiens	O95777	Y2H	21988832
Intra	LSM3	P62310	LSM8	Homo sapiens	O95777	Y2H	22365833
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Validated Y2H	32296183
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Y2H Array	32296183
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Y2H	15231747
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	LSM7	Homo sapiens	Q9UK45	Y2H	22365833
Intra	LSM3	P62310	YBX1	Homo sapiens	P67809	Y2H	22365833
Intra	LSM3	P62310	SNRPF	Homo sapiens	P62306	Y2H Array	32296183
Intra	LSM3	P62310	SNRPF	Homo sapiens	P62306	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	CEP95	Homo sapiens	Q96GE4	Anti Tag CoIP	33961781
Intra	LSM3	P62310	CEP95	Homo sapiens	Q96GE4	Y2H	15231747
Intra	LSM3	P62310	SNRPD3	Homo sapiens	P62318	Validated Y2H	32296183
Intra	LSM3	P62310	SNRPD3	Homo sapiens	P62318	Y2H Array	32296183
Intra	LSM3	P62310	SNRPD3	Homo sapiens	P62318	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	SNRPD3	Homo sapiens	P62318	Y2H	15231747
Intra	LSM3	P62310	LSM5	Homo sapiens	Q9Y4Y9	Validated Y2H	32296183
Intra	LSM3	P62310	LSM5	Homo sapiens	Q9Y4Y9	Y2H	15231747
Intra	LSM3	P62310	LSM5	Homo sapiens	Q9Y4Y9	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM10	Homo sapiens	Q969L4	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM10	Homo sapiens	Q969L4	Y2H	15231747
Intra	LSM3	P62310	LSM10	Homo sapiens	Q969L4	Y2H Pooling	16189514
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	25416956
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Y2H	15231747
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Y2H Array	32296183
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Anti Tag CoIP	33961781
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Validated Y2H	32296183
Intra	LSM3	P62310	LSM6	Homo sapiens	P62312	Validated Y2H	25416956
Intra	LSM3	P62310	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	INCA1	Homo sapiens	Q0VD86	Validated Y2H	32296183
Intra	LSM3	P62310	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Y2H	22365833
Intra	LSM3	P62310	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	25416956
Intra	LSM3	P62310	LSM12	Homo sapiens	Q3MHD2	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	LSM12	Homo sapiens	Q3MHD2	Validated Y2H	32296183
Intra	LSM3	P62310	LSM12	Homo sapiens	Q3MHD2	Y2H Array	32296183
Intra	LSM3	P62310	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	LSM3	P62310	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	LSM3	P62310	TCL1A	Homo sapiens	P56279	Y2H Prey Pooling	25416956
Intra	LSM3	P62310	KEAP1	Homo sapiens	Q14145	Y2H Array	32296183
Intra	LSM3	P62310	KEAP1	Homo sapiens	Q14145	Y2H Array	25416956
Intra	LSM3	P62310	KEAP1	Homo sapiens	Q14145	Validated Y2H	32296183
Intra	LSM3	P62310	KEAP1	Homo sapiens	Q14145	Validated Y2H	25416956
Intra	LSM3	P62310	KEAP1	Homo sapiens	Q14145	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	NACC1	Homo sapiens	Q96RE7	Y2H Prey Pooling	32296183
Intra	LSM3	P62310	NACC1	Homo sapiens	Q96RE7	Y2H Array	32296183
Intra	LSM3	P62310	NACC1	Homo sapiens	Q96RE7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LSM3 Proteins

Cat. No.	상품명	Accession	Purity
HY-P75915	LSM3 Protein, Human (His)	P62310 /NP_055278.1(M1-G102)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Coffin-Siris Syndrome 3	CSS3 Mrd15 Mental Retardation, Autosomal Dominant 15 Autosomal Dominant Mental Retardation 15 Coffin-Siris Syndrome, Type 3
Spondylolysis	Acquired Spondylolysis
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07858	LSM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19913	Lsm3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26414	Lsm3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LSM3	RGD	RGD:1305971
Bos taurus	LSM3	VGNC	VGNC:31055
Canis familiaris	LSM3	VGNC	VGNC:42843
Mus musculus	LSM3	MGD	MGI:1914928
Others	LSM3	NCBI