BChE-IN-36
hBChE-IN-4 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. hBChE-IN-4 shows no cytotoxicity. hBChE-IN-4 shows potent procognitive effects. hBChE-IN-4 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders.
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- 화학식: C26H35N5O2
- 분자량:449.59
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
EeAChE 72.1 nM (IC50) |
eqBCHE 4.2 nM (IC50) |
hCA I 266 nM (KA) |
hCA II 76.9 nM (KA) |
hCA VB 893 nM (KA) |
hCA IV 918 nM (KA) |
hCA VII 98.0 nM (KA) |
Chemical Information
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분자량 449.59
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화학식 C26H35N5O2
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SMILES
O=C([C@@H](NCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31)CC4=CNC=N4)OC
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)