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Cat. No.: HY-120042

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Heptenophos

Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies.

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CAS No.: 23560-59-0
화학식: C₉H₁₂ClO₄P
분자량:250.61

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Heptenophos Chemical Structure

CAS No.: 23560-59-0

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- 제품 설명
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- In Vivo
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Biological Activity

제품 설명

IC₅₀ & Target

AChE

All Carboxylesterase (CES) Isoforms :

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vivo

Heptenophos (1.3 LD₅₀; intravenous injection; single administration) strongly inhibits central, peripheral and erythrocyte AChE as well as plasma CES in male albino mice, with an intravenous LD₅₀ of 196.68 μmol/kg. In contrast, Trimedoxime (HY-165600A) exerts time-dependent protective efficacy in Heptenophos-poisoned mice, with an ED₅₀ of 14.66 μmol/kg, and can reactivate brain and diaphragm AChE as well as plasma CES^[1].
The intravenous LD₅₀ of Heptenophos in male albino mice is 196.68 μmol/kg. When administered in combination, obidoxime chloride (HY-W011108) at an ED₅₀ of 21.56 μmol/kg is required to achieve a 50% survival rate (Heptenophos at 1.3 LD50; intravenous injection; single administration)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

albino mice (male, 18-24 g)^[1]
Dosage:

1.3 LD₅₀; 196.68 μmol/kg (LD₅₀)
Administration:

i.v.; single dose
Result:

Induced severe inhibition of central, peripheral, and erythrocyte AChE as well as plasma carboxylesterase, leaving 3.33% of erythrocyte AChE, 3.37% of brain AChE, 13.05% of diaphragmal AChE, and 7.3% of plasma carboxylesterase activity uninhibited.
Reached an intravenous LD₅₀ of 196.68 μmol/kg (95% confidence interval: 163.72-208.41).

Animal Model:

Albino mice (male, 18-24 g)^[2]
Dosage:

1.3 LD₅₀ (toxic challenge); 196.68 μmol/kg (LD₅₀ determination)
Administration:

i.v.; single dose
Result:

Determined an intravenous LD₅₀ of 196.68 μmol/kg (95% confidence interval: 163.72-208.41 μmol/kg).
Required an obidoxime ED₅₀of 21.56 μmol/kg to achieve 50% survival when administered concurrently with 1.3 LD₅₀ heptenophos.

Chemical Information

CAS No. 23560-59-0
분자량 250.61
화학식 C₉H₁₂ClO₄P
SMILES

O=P(OC1=C(Cl)C2C=CCC12)(OC)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Antonijević B, et al. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. Basic Clin Pharmacol Toxicol. 2005;96(2):111-117. [Content Brief]

[2]. Antonijević B, et al. Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom[J]. Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, 2011, 68(12).

Calculators

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vivo
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Heptenophos

All Carboxylesterase (CES) Isoforms

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Heptenophos Related Classifications

HY-120042 Related Classifications