JAK-IN-33
JAK-IN-33 (compound 3 (R)) is a JAK inhibitor.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3032404-49-9
- 화학식: C24H27N5O5
- 분자량:465.50
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
JAK-IN-33 can be effectively applied in blood[1].
JAK-IN-33 (59 μM, 40 h) can significantly reduce the elevation of GSVA (gene set variation analysis) score stimulated by IL4/IL3 in the human skin, making GSVA score more normal[1].
JAK-IN-33 (59 μM, 40 h) has acceptable stability in the human skin, and can be effectively applied in human skin[1].
JAK-IN-33 (0.324 μL, 40 h) significantly inhibits the expression of TARC and two AD (atopic dermatitis) relevant biomarkers MMP12 and Eotaxin 3 in the Franz cells[1].
JAK-IN-33 is rapidly inactivated in the liver and is expected to have a better targeted systemic safety profile after topical application compares to oral JAK inhibitors repurposed for topical ues.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Franz
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Concentration:0.324 μL
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Incubation Time:40 h
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Result:Significantly inhibited the expression of TARC, MMP12 and Eotaxin 3.
Chemical Information
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CAS No. 3032404-49-9
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분자량 465.50
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화학식 C24H27N5O5
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SMILES
COC[C@H](OC(CC1=CC=C(N=C1)NC2=CC(NC3=CC=CC=C3OC)=C(C=N2)C(N)=O)=O)C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK-IN-33 Related Classifications
HY-157011 Related Classifications
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