N-Nitrosonornicotine
Based on 1 Customer Validation
N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts.
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- Purity: 99.97%
- CAS No.: 16543-55-8
- 화학식: C9H11N3O
- 분자량:177.20
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보관:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Chemical Information
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CAS No. 16543-55-8
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Appearance Solid
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분자량 177.20
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화학식 C9H11N3O
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Color White to off-white
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SMILES
O=NN1[C@H](C2=CN=CC=C2)CCC1
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Synonyms
(2S)-N'-Nitrosonornicotine
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
DMSO : 83.33 mg/mL (470.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774. [Content Brief]
[2]. Shugo Suzuki, et al. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. 2020 Jan 15:429:152325. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6433 mL | 28.2167 mL | 56.4334 mL | 141.0835 mL |
| 5 mM | 1.1287 mL | 5.6433 mL | 11.2867 mL | 28.2167 mL | |
| 10 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL | 14.1084 mL | |
| 15 mM | 0.3762 mL | 1.8811 mL | 3.7622 mL | 9.4056 mL | |
| 20 mM | 0.2822 mL | 1.4108 mL | 2.8217 mL | 7.0542 mL | |
| 25 mM | 0.2257 mL | 1.1287 mL | 2.2573 mL | 5.6433 mL | |
| 30 mM | 0.1881 mL | 0.9406 mL | 1.8811 mL | 4.7028 mL | |
| 40 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5271 mL | |
| 50 mM | 0.1129 mL | 0.5643 mL | 1.1287 mL | 2.8217 mL | |
| 60 mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 2.3514 mL | |
| 80 mM | 0.0705 mL | 0.3527 mL | 0.7054 mL | 1.7635 mL | |
| 100 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4108 mL |
N-Nitrosonornicotine Related Classifications
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