16543-55-8
16543-55-8
Chemical Structure
N-Nitrosonornicotine
Synonym(s): (2S)-N'-Nitrosonornicotine
- CAS No.: 16543-55-8
- Formula:C9H11N3O
- Molecular Weight:177.20
IUPAC Name: (S)-3-(1-nitrosopyrrolidin-2-yl)pyridine
InChIKey: XKABJYQDMJTNGQ-VIFPVBQESA-N
SMILES: O=NN1[C@H](C2=CN=CC=C2)CCC1
Biological Activity: N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Nitrosonornicotine | 99.97% | N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts. | ||||||||||||||||||||
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N-Nitrosonornicotine-d4 | N-Nitrosonornicotine-d4 ((2S)-N'-Nitrosonornicotine-d4) is deuterium labeled N-Nitrosonornicotine. N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts. | |||||||||||||||||||||
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(±)-N′-Nitrosonornicotine-2,4,5,6-d4 | 99.12% | (±)-N′-Nitrosonornicotine-2,4,5,6-d4 is the deuterium labeled (±)-N′-Nitrosonornicotine-2,4,5,6. | ||||||||||||||||||||
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References
- [1]. Yijing Chen, et al. Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes. Toxicology. 2024 May:504:153774. [Content Brief]
- [2]. Shugo Suzuki, et al. Cotinine, a major nicotine metabolite, induces cell proliferation on urothelium in vitro and in vivo. Toxicology. 2020 Jan 15:429:152325. [Content Brief]
