PDE1-IN-5
PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD.
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- CAS No.: 2982945-34-4
- 화학식: C27H29FN4O
- 분자량:444.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
15 nM (PDE1C)[1]
Chemical Information
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CAS No. 2982945-34-4
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분자량 444.54
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화학식 C27H29FN4O
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SMILES
O=C1C(C#N)=C(C2=CC=C(C=C2N1CC3CCCC3)NCC4=CC=C(C=N4)F)C5CCCC5
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE1-IN-5 Related Classifications
HY-155199 Related Classifications
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