2982945-34-4
2982945-34-4
Chemical Structure
PDE1-IN-5
- CAS No.: 2982945-34-4
- Formula:C27H29FN4O
- Molecular Weight:444.54
InChIKey: ZACDRXGBWRHLCR-UHFFFAOYSA-N
SMILES: O=C1C(C#N)=C(C2=CC=C(C=C2N1CC3CCCC3)NCC4=CC=C(C=N4)F)C5CCCC5
Biological Activity: PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD[1].
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PDE1-IN-5 | PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD. | |||||||||||||||||||||
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References
Keywords
