Prifinium bromide
Based on 1 Customer Validation
Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.41%
- CAS No.: 4630-95-9
- 화학식: C22H28BrN
- 분자량:386.37
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Prifinium bromide inhibits carbamoylcholine chloride (HY-B1208)-induced contraction of isolated guinea pig detrusor muscle, but exerts almost no effect on contractions induced by electrical stimulation, KCl or BaCl2[1].
Prifinium bromide exhibits anticholinergic activity in isolated guinea pig ileum, with a relative potency of 0.45 compared with Atropine (HY-B1205)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4630-95-9
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Appearance Solid
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분자량 386.37
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화학식 C22H28BrN
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Color White to off-white
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SMILES
CC1[N+](CC)(CC/C1=C(C2=CC=CC=C2)\C3=CC=CC=C3)CC.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (258.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Terai T, et al. Effects of the anticholinergic drug prifinium bromide on urinary bladder contractions in rat in vivo and in guinea-pig in vitro. Arzneimittelforschung. 1991;41(4):417-420. [Content Brief]
[2]. Ohki S, et al. Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. XII. Synthesis and Anticholinergic Activity of 1,1-Dialkyl-3-diphenylmethylene-2,4-dimethylpyrrolidinium Halides. Chem Pharm Bull. 1986;34(9):3606-3613. [Content Brief]
[3]. Sasaki D, et al. Anti-spasmodic effect of prifinium bromide on the proximal and distal colon in patients with diverticular disease. Gastroenterol Jpn. 1981;16(4):344-349. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5882 mL | 12.9410 mL | 25.8819 mL | 64.7048 mL |
| 5 mM | 0.5176 mL | 2.5882 mL | 5.1764 mL | 12.9410 mL | |
| 10 mM | 0.2588 mL | 1.2941 mL | 2.5882 mL | 6.4705 mL | |
| 15 mM | 0.1725 mL | 0.8627 mL | 1.7255 mL | 4.3137 mL | |
| 20 mM | 0.1294 mL | 0.6470 mL | 1.2941 mL | 3.2352 mL | |
| 25 mM | 0.1035 mL | 0.5176 mL | 1.0353 mL | 2.5882 mL | |
| 30 mM | 0.0863 mL | 0.4314 mL | 0.8627 mL | 2.1568 mL | |
| 40 mM | 0.0647 mL | 0.3235 mL | 0.6470 mL | 1.6176 mL | |
| 50 mM | 0.0518 mL | 0.2588 mL | 0.5176 mL | 1.2941 mL | |
| 60 mM | 0.0431 mL | 0.2157 mL | 0.4314 mL | 1.0784 mL | |
| 80 mM | 0.0324 mL | 0.1618 mL | 0.3235 mL | 0.8088 mL | |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2588 mL | 0.6470 mL |
Prifinium bromide Related Classifications
HY-122086 Related Classifications
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