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Cat. No.: HY-152080A

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(R)-Blovacitinib

(Synonyms: (R)-TUL01101)

(R)-Blovacitinib ((R)-TUL01101) is a JAK1-selective inhibitor with an IC₅₀ of 45 nM. (R)-Blovacitinib inhibits JAK1-mediated cytokine signaling pathways. (R)-Blovacitinib can be used for the research of rheumatoid arthritis.

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CAS No.: 2411222-96-1
화학식: C₂₂H₂₅F₂N₅O₂
분자량:429.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

(R)-Blovacitinib Chemical Structure

CAS No.: 2411222-96-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

JAK1

45 nM (IC₅₀)

All JAK Isoforms :

In Vitro

(R)-Blovacitinib (compound 35) inhibits purified human JAK1 with an IC₅₀ of 45 nM, showing 11.7-fold selectivity over JAK2 and 8.0-fold selectivity over TYK2, with no significant inhibition of JAK3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2411222-96-1
분자량 429.46
화학식 C₂₂H₂₅F₂N₅O₂
SMILES

O=C([C@@H]1C(F)(C1)F)N2CC3(CCC(C4=CC=CC5=NC(NC(C6CC6)=O)=NN45)CC3)C2
Synonyms

(R)-TUL01101
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhou S, et al. Identification of TUL01101: A Novel Potent and Selective JAK1 Inhibitor for the Treatment of Rheumatoid Arthritis. Journal of medicinal chemistry. 2022 Dec 22;65(24):16716-16740. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
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References

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(R)-Blovacitinib

All JAK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(R)-Blovacitinib Related Classifications

HY-152080A Related Classifications