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Cat. No.: HY-101384

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Ro 10-5824

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Ro 10-5824 is a potent and selective D4R partial agonist with a K_i of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice.

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CAS No.: 189744-46-5
화학식: C₁₇H₂₀N₄
분자량:280.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Ro 10-5824 Chemical Structure

CAS No.: 189744-46-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Publications (2)
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Biological Activity

제품 설명

Ro 10-5824 is a potent and selective D4R partial agonist with a K_i of 5.2 nM. Ro 10-5824 increases novel object exploration in C57 mice^[1]^[2].

IC₅₀ & Target

Dopamine D4 receptor

All Dopamine Receptor Isoforms :

Chemical Information

CAS No. 189744-46-5
분자량 280.38
화학식 C₁₇H₂₀N₄
SMILES

N=1C=C(C(=NC1C)N)CN2CC=C(C=3C=CC=CC3)CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Br J Pharmacol

Requirement of sigma-1 receptor (Sig-1R) for boosting the gamma oscillations in the medial prefrontal cortex (mPFC). [Abstract]

2026 Aug;183(15):4178-4195. PMID: 42025290
Brain Behav Immun

Neural network disturbance in the medial prefrontal cortex might contribute to cognitive impairments induced by neuroinflammation. [Abstract]

2020 Oct:89:133-144. PMID: 32505714

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44(4):473-81. [Content Brief]

[2]. Cummings DF, et al. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548. J Pharmacol Exp Ther. 2010 Jun;333(3):682-95. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Ro 10-5824

2 Cited Publications

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Publications (2)
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Ro 10-5824

Publications Citing Use of MedChemExpress (MCE) Ro 10-5824

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

순도&문서

References

Calculators

Help & FAQs

Ro 10-5824 Related Classifications

HY-101384 Related Classifications