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Talacotuzumab

(Synonyms: JNJ 56022473; CSL 362)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models.

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  • Experimental Validation Results for Talacotuzumab
  • Experimental Validation Results for Talacotuzumab
  • Experimental Validation Results for Talacotuzumab
  • Talacotuzumab Chemical Structure
    Talacotuzumab Chemical Structure
CAS No.: 1826831-79-1
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IL-3R alpha/CD123 Protein, Human can bind Talacotuzumab. The EC50 for this effect is 6.855 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 THP-1 cells labeling Talacotuzumab (HY-P99395, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Talacotuzumab Chemical Structure
    1/16
  • Talacotuzumab
  • Immobilized IL-3R alpha/CD123 Protein, Human can bind Talacotuzumab. The EC50 for this effect is 6.855 ng/mL.
  • Flow cytometric analysis of 1.5X106 THP-1 cells labeling Talacotuzumab (HY-P99395, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).