WZH-17-002
WZH-17-002 is a WZH-15-125-based ALK PROTAC degrader with a DC50 of 25 nM. WZH-17-002 enhances activities against Lorlatinib (HY-12215)-resistant ALK compound mutations. WZH-17-002 significantly reduces drug resistance in ALK-fusion non-small cell lung cancer (NSCLC) and inhibits tumor growth in EML4-ALK G1202R/L1196 M xenograft mice model. Pink: ALK ligand (HY-174314); Blue: CRBN ligase ligand (HY-14658); Black: linker (HY-174316)
(Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-174314); Blue: Cereblon ligand (HY-14658); Black: linker (HY-174316)).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C47H54BrN11O10S
- 분자량:1044.97
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All PROTACs Isoforms
More
Biological Activity
| Species | Dose | Route | AUClast | AUC0-∞ | T1/2 | Vss | CL | Cmax | Tmax | F |
|---|---|---|---|---|---|---|---|---|---|---|
| Rat | 1 mg/kg | i.v. | 4279 ng·h/mL | 4317 ng·h/mL | 3.48 h | 0.99 L/kg | 4.19 mL/min/kg | / | / | / |
| Rat | 10 mg/kg | p.o. | 3578 ng·h/mL | 3675 ng·h/mL | 4.07 h | / | / | 269 ng/mL | 4.67 h | 8.5 % |
Chemical Information
-
분자량 1044.97
-
화학식 C47H54BrN11O10S
-
SMILES
O=C(N(CC1)CCN1C(CC2)CCN2C(C(CC)=C3)=CC(OC)=C3NC(N=C4NC5=CC=C6OCCOC6=C5N(S(C)(=O)=O)C)=NC=C4Br)CNC7=C8C(N(C9CCC(NC9=O)=O)C(C8=CC=C7)=O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WZH-17-002 Related Classifications
HY-174315 Related Classifications
Powered by Bioz