Laccaic acid A 

Laccaic acid A is a orally active and DNA-competitive inhibitor of DNA methyltransferase 1 (Dnmt1) (K_i=310 nM; IC₅₀=650 nM). Laccaic acid A has stronger Dnmt1 inhibitory effect than SG-1027 (HY-13962). Laccaic acid A combined with Phenethyl isothiocyanate has a strong synergistic effect on colorectal cancer^[1][2].

Laccaic acid A (200 μM) alters the expression of methylated genes in MCF-7 breast cancer cells synergistically with 0.5 μM Decitabine (HY-A0004)^[1][1].
Laccaic acid A (0.01-100 μM; 24 h, 48 h, and 72 h) inhibits human colon carcinoma HT29 growth with an IC50 value of 6.08 μM for 72 h-treatment^[2].
Laccaic acid A (6.08 μM) induces cell apoptosis and arrests cell cycle at sub-G1 phase in HT29^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Laccaic acid A (50 mg/kg, 100 mg/kg, and 200 mg/kg; p.o.; once daily for 21 d) improves the colon carcinoma model in rats^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

537.43

C₂₆H₁₉NO₁₂

15979-35-8

O=C(C(C(C(O)=O)=C(O)C=C1C(C2=C3C(O)=C(C4=CC(CCNC(C)=O)=CC=C4O)C(O)=C2O)=O)=C1C3=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Fagan RL, et al. Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. J Biol Chem. 2013 Aug 16;288(33):23858-67.  [Content Brief]

  [2]. Gupta R, et al. Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1. Toxicol Appl Pharmacol. 2019 Aug 15;377:114631.  [Content Brief]