1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Metipranolol

Metipranolol 

Cat. No.: HY-121567 Purity: 98.36%
Handling Instructions

Metipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research.

For research use only. We do not sell to patients.

Metipranolol Chemical Structure

Metipranolol Chemical Structure

CAS No. : 22664-55-7

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 220 In-stock
Estimated Time of Arrival: December 31
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg USD 620 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Metipranolol is a nonselective and orally active β-adrenergic receptor antagonist. Metipranolol can be used for hypertension and glaucoma research[1][2].

IC50 & Target[2]

β1 adrenoceptor

8.3 (pA2)

β2 adrenoceptor

8.4 (pA2)

In Vitro

In vitro β1- and β2-adrenoceptor antagonism is evaluated using the guinea pig atrium and the rat uterus, respectively. The respective pA2 values are 8.3 and 8.4[2].
Metipranolol significantly reduces iron/ascorbate-induced lipid peroxidation in rat brain homogenates with an IC50 value of 6.9 μM . Metipranolol also concentration-dependently inhibits sodium nitroprusside-stimulated lipid peroxidation in rat brain homogenates, displaying an IC50 value of 25.1 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

At postnatal day 35 (P35), rd10 mice given daily subcutaneous injections of 40 mg/kg of Metipranolol has reduction in markers of nitrosative stress, fewer TUNEL-positive cells, increased outer nuclear layer thickness, and substantially more staining for rhodopsin. At P50, Metipranolol-treated rd10 mice has decreased 3-nitrotyrosine staining in the retina, increased immunostaining for cone arrestin, a marker for cone photoreceptors, and significantly higher scotopic and photopic b-wave amplitudes at the highest stimulus intensity. At P65, cone density is significantly higher in Metipranolol-treated versus vehicle-injected rd10 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

309.40

Formula

C₁₇H₂₇NO₄

CAS No.
SMILES

CC(OC1=C(C=C(C(C)=C1C)OCC(CNC(C)C)O)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (808.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2321 mL 16.1603 mL 32.3206 mL
5 mM 0.6464 mL 3.2321 mL 6.4641 mL
10 mM 0.3232 mL 1.6160 mL 3.2321 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.72 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.72 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.72 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MetipranololAdrenergic ReceptorBeta ReceptorNitrosativestresshypertensionglaucomaantioxidantlipidperoxidationInhibitorinhibitorinhibit

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Metipranolol
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HY-121567
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