1. Anti-infection
  2. HCV
  3. MK-0608

MK-0608 

Cat. No.: HY-10244
Handling Instructions

MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.

For research use only. We do not sell to patients.

MK-0608 Chemical Structure

MK-0608 Chemical Structure

CAS No. : 443642-29-3

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Description

MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1].

IC50 & Target

EC50: 0.3 μM (HCV replication)[1]

In Vivo

Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively)[1].

Animal Model: The HCV-infected chimpanzees[1]
Dosage: 1 mg/kg
Administration: Administered orally; once daily for 37 days
Result: Chimpanzee X6 had a baseline viral load that varied from 1,110 to 12,900 IU/mL, and chimpanzee X4 had a baseline viral load of 3×106 to 9×106 IU/mL.
Molecular Weight

280.28

Formula

C₁₂H₁₆N₄O₄

CAS No.

443642-29-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MK-0608MK0608MK 0608HCVHepatitis C virusInhibitorinhibitorinhibit

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