443642-29-3
443642-29-3
Chemical Structure
MK-0608
- CAS No.: 443642-29-3
- Formula:C12H16N4O4
- Molecular Weight:280.28
IUPAC Name: (2R,3R,4R,5R)-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
InChIKey: IRZRJANZDIOOIF-GAJNKVMBSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@](O)(C)[C@H](N2C=CC3=C2N=CN=C3N)O1
Biological Activity: MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay[1].
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MK-0608 | 99.81% | MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay. | ||||||||||||||||||||
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MK-0608 (Standard) | ≥98% | MK-0608 (Standard) is the analytical standard of MK-0608 (HY-10244). This product is intended for research and analytical applications. MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.86
HY-12957NITD008 -
Similarity Score 0.86
![4-Chloro-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine Chemical Structure](//file.medchemexpress.com/product_pic/hy-152818.gif)
HY-1528184-Chloro-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine -
Similarity Score 0.82
![4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Chemical Structure](//file.medchemexpress.com/product_pic/hy-152819.gif)
HY-1528194-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine -
Similarity Score 0.82
HY-162517UMM-766 -
Similarity Score 0.81
HY-100126RTubercidin (Standard) -
Similarity Score 0.79
HY-1786322'-O-Me-7-deaza-rA -
Similarity Score 0.78
HY-1253712'-C-Methyladenosine -
Similarity Score 0.77
HY-W0485137-Deaza-2'-deoxyadenosine -
Similarity Score 0.77
![7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Structure](//file.medchemexpress.com/product_pic/hy-152582.gif)
HY-1525827-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine -
Explore the MedChemAI to find more analogs
![4-Chloro-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d] pyrimidine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-152818.gif)
![4-Amino-5-iodo-7-(2-β-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-152819.gif)
![7-(3-Deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Structure](http://file.medchemexpress.com/product_pic/hy-152582.gif)
