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Cat. No.: HY-186238

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VVZ-068

VVZ-068 is a benzamide derivative and also a GlyT2/5HT2A antagonist. VVZ-068 alleviates neuropathic mechanical hyperalgesia in a rat model of mechanical allodynia. VVZ-068 is applicable for pain-related research.

For research use only. We do not sell to patients.

CAS No.: 1440797-80-7
Formula: C₂₀H₃₂N₂O₅
Molecular Weight:380.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VVZ-068 Chemical Structure

CAS No.: 1440797-80-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GlyT2

5-HT_2A Receptor

All GlyT Isoforms :

GlyT1
GlyT2

All 5-HT Receptor Isoforms :

In Vitro

VVZ-068 (10 μM) inhibits GlyT2 in 293T cells stably expressing rat GlyT2, and inhibits 5HT2A in 293T cells expressing human 5HT2A^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

VVZ-068 (50-100 mg/kg, s.c./p.o., single administration) significantly increases the paw withdrawal threshold in rats with mechanical allodynia induced by L5/L6 spinal nerve ligation, and rapidly alleviates neuropathic mechanical hyperalgesia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats, 100-120 g^[1]
Dosage:

50 (s.c.), 100 (p.o.) mg/kg
Administration:

s.c./p.o., single administration
Result:

Significantly increased the paw withdrawal threshold in rats with mechanical allodynia induced by L5/L6 spinal nerve ligation, and rapidly alleviated neuropathic mechanical hyperalgesia.

Chemical Information

CAS No. 1440797-80-7
Molecular Weight 380.48
Formula C₂₀H₃₂N₂O₅
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OCCCC)NCC2(CCOCC2)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee Du-hyeon, et al. Novel benzamide derivative and use thereof. WO2013081400A2. 2014-05-29

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC50 & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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VVZ-068

All GlyT Isoforms

All 5-HT Receptor Isoforms