1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Phentolamine mesylate

Phentolamine mesylate  (Synonyms: Phentolamine methanesulfonate)

Cat. No.: HY-B0362A Purity: 99.90%
COA Handling Instructions

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction.

For research use only. We do not sell to patients.

Phentolamine mesylate Chemical Structure

Phentolamine mesylate Chemical Structure

CAS No. : 65-28-1

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Phentolamine mesylate:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Phentolamine mesylate

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

IC50 & Target

α-adrenergic[1]

In Vitro

Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively[3].
Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively[4].
Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) significantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner[4].
Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

377.46

Formula

C18H23N3O4S

CAS No.
SMILES

CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (132.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6493 mL 13.2464 mL 26.4929 mL
5 mM 0.5299 mL 2.6493 mL 5.2986 mL
10 mM 0.2649 mL 1.3246 mL 2.6493 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (264.93 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Phentolamine mesylate
Cat. No.:
HY-B0362A
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